Abstract | BACKGROUND: STUDY DESIGN AND METHODS: Herein, we describe two patients with severe WAIHA treated at our center, who obtained a response after therapeutic plasma exchanges (TPEs) combined with low doses of IVIG. RESULTS: The first patient was an 18-year-old man with no relevant past medical history who was diagnosed with WAIHA. The patient presented a progressive clinical worsening despite treatment with prednisone, IVIG, and rituximab. After starting TPEs, signs of hemolysis rapidly improved and hemoglobin started to recover. The second patient was a 38-year-old man with a past history of immune thrombocytopenia and WAIHA. The patient presented a new flare of WAIHA, with no response after 2 weeks of treatment with corticosteroids, IVIG, and rituximab. After initiation of TPEs, the patient had an improvement in hemolysis biomarkers and recovery of hemoglobin concentration. CONCLUSION: Combination of TPEs with rituximab and IVIG might be considered as a therapeutic option in patients with severe WAIHA without response to corticosteroid and IVIG treatment.
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Authors | Irene García-García, Joan Cid, Alicia Palomino, Eva Giné, Alberto Alvarez-Larrán, María T Cibeira, Miquel Lozano |
Journal | Transfusion
(Transfusion)
Vol. 60
Issue 11
Pg. 2753-2757
(11 2020)
ISSN: 1537-2995 [Electronic] United States |
PMID | 33089904
(Publication Type: Case Reports)
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Copyright | © 2020 AABB. |
Chemical References |
- Immunoglobulins, Intravenous
- Rituximab
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Topics |
- Adolescent
- Adult
- Anemia, Hemolytic, Autoimmune
(blood, diagnosis, therapy)
- Humans
- Immunoglobulins, Intravenous
(administration & dosage)
- Male
- Plasma Exchange
- Rituximab
(administration & dosage)
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