[The effect of various forms of folates on cognitive functions in patients with chronic schizophrenia].

Abstract

OBJECTIVE:

To assess the dynamics of cognitive functions in patients with schizophrenia during intake of various forms of folate as an add-on to antipsychotic therapy.

MATERIAL AND METHODS:

Using a battery of cognitive tests, the authors evaluated the dynamics of cognitive functions in 3 groups of patients with schizophrenia who received folic acid (n=25), metafolin (n=25) during 4 weeks and in the control group (n=25). Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR. Only the carriers of the minor T allele were included in the study.

RESULTS AND CONCLUSION:

The improvement of certain cognitive functions was noted after folate administration, it was more pronounced and statistically significant in the metapholin group. The results hold promises for further studies of prolonged use of folate in prophylactic doses for schizophrenia.

• Authors: T V Zhilyaeva, A S Blagonravova, G E Mazo
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 120 Issue 9 Pg. 87-92 ( 2020) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Vliyanie raznykh form folatov na kognitivnye funktsii u bol'nykh khronicheskoi shizofreniei.
• PMID: 33081452 (Publication Type: Journal Article)

Chemical References

• Folic Acid
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Cognition
• Folic Acid
• Humans
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Polymorphism, Genetic
• Schizophrenia (drug therapy, genetics)