Abstract |
To ensure the safety of high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT), evidence-based recommendations on infectious complications after HDC/ASCT are given. This guideline not only focuses on patients with haematological malignancies but also addresses the specifics of HDC/ASCT patients with solid tumours or autoimmune disorders. In addition to HBV and HCV, HEV screening is nowadays mandatory prior to ASCT. For patients with HBs antigen and/or anti-HBc antibody positivity, HBV nucleic acid testing is strongly recommended for 6 months after HDC/ASCT or for the duration of a respective maintenance therapy. Prevention of VZV reactivation by vaccination is strongly recommended. Cotrimoxazole for the prevention of Pneumocystis jirovecii is supported. Invasive fungal diseases are less frequent after HDC/ASCT, therefore, primary systemic antifungal prophylaxis is not recommended. Data do not support a benefit of protective room ventilation e.g. HEPA filtration. Thus, AGIHO only supports this technique with marginal strength. Fluoroquinolone prophylaxis is recommended to prevent bacterial infections, although a survival advantage has not been demonstrated.
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Authors | Maximilian Christopeit, Martin Schmidt-Hieber, Rosanne Sprute, Dieter Buchheidt, Marcus Hentrich, Meinolf Karthaus, Olaf Penack, Markus Ruhnke, Florian Weissinger, Oliver A Cornely, Georg Maschmeyer |
Journal | Annals of hematology
(Ann Hematol)
Vol. 100
Issue 2
Pg. 321-336
(Feb 2021)
ISSN: 1432-0584 [Electronic] Germany |
PMID | 33079221
(Publication Type: Journal Article, Review)
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Chemical References |
- Hepatitis B Antibodies
- RNA, Viral
- Trimethoprim, Sulfamethoxazole Drug Combination
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Topics |
- Germany
- Hematologic Neoplasms
(therapy)
- Hematology
- Hematopoietic Stem Cell Transplantation
- Hepacivirus
(metabolism)
- Hepatitis B
(blood, prevention & control)
- Hepatitis B Antibodies
(blood)
- Hepatitis B virus
(metabolism)
- Hepatitis C
(blood, prevention & control)
- Humans
- Medical Oncology
- Pneumocystis carinii
(metabolism)
- Pneumonia, Pneumocystis
(blood, prevention & control)
- Practice Guidelines as Topic
- RNA, Viral
(blood)
- Societies, Medical
- Transplantation, Autologous
- Trimethoprim, Sulfamethoxazole Drug Combination
(therapeutic use)
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