Hyperglycemia and
hyperuricemia are both metabolic disorders related to excessive amount of metabolites in blood, which are considered as high risk factors for the development of many
chronic diseases.
Enzymes, cells, tissues and organs, which are relevant to metabolism and excretion of
glucose and UA, are usually regarded to be the targets in treatment of
hyperglycemia and
hyperuricemia. Several drugs have been commonly applied to combat
hyperglycemia and
hyperuricemia through various targets but with unignorable side effects.
Anthocyanins have become promising alternatives against
hyperglycemia and
hyperuricemia because of their bio-activities with little side effects. Structurally different
anthocyanins from berry fruits, cherries and purple sweet potato lead to the diverse functional activity and property. This review is aimed to illustrate the specific targets that are available for
anthocyanins from berry fruits, cherries and purple sweet potato in
hyperglycemia and
hyperuricemia management, as well as discuss the structure-activity relationship, and the underlying mechanisms associated with intracellular signaling pathway, anti-oxidative stress and anti-
inflammation. In addition, the relationship of
hyperglycemia and
hyperuricemia, and the possibly regulative role of
anthocyanins against them, along with the effects of
anthocyanins in clinical trial are mentioned.