CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients.
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| Abstract |
The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.
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| Authors | Mingming Jin, Nannan Shi, Meng Wang, Chunzi Shi, Shengjie Lu, Qing Chang, Shuang Sha, Yun Lin, Yingmin Chen, Hui Zhou, Kaiyi Liang, Xuyuan Huang, Yuxin Shi, Gang Huang |
| Journal | Aging (Aging (Albany NY)) Vol. 12 Issue 20 Pg. 19867-19879 (10 16 2020) ISSN: 1945-4589 [Electronic] United States |
| PMID | 33065551 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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