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mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19.

AuthorsYan Tang, David J Kwiatkowski, Elizabeth P Henske
JournalThe European respiratory journal (Eur Respir J) Vol. 57 Issue 2 (02 2021) ISSN: 1399-3003 [Electronic] England
PMID33060154 (Publication Type: Letter)
Chemical References
  • Antibiotics, Antineoplastic
  • IL6 protein, human
  • Interleukin-6
  • Interferons
  • Mechanistic Target of Rapamycin Complex 1
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Sirolimus
Topics
  • Alveolar Epithelial Cells (metabolism, pathology)
  • Angiotensin-Converting Enzyme 2 (genetics)
  • Antibiotics, Antineoplastic (pharmacology)
  • COVID-19 (metabolism, virology)
  • Cancer-Associated Fibroblasts (metabolism)
  • Humans
  • Interferons (metabolism)
  • Interleukin-6 (metabolism)
  • Lymphangioleiomyomatosis (metabolism, pathology)
  • Mechanistic Target of Rapamycin Complex 1 (metabolism)
  • SARS-CoV-2 (physiology)
  • Signal Transduction (drug effects)
  • Sirolimus (pharmacology)
  • Up-Regulation (drug effects)

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