Abstract | OBJECTIVES: METHODS: This cross-sectional study included 298 adults (137 men and 161 women) without clinical history of CVD or cancer. The pyrosequencing method was used to measure leukocyte ABCA1 DNA methylation levels. Dietary fish and FA intakes were assessed based on the validated food frequency questionnaire. RESULTS: Mean ABCA1 DNA methylation levels were significantly lower in the highest fish intake groups (≥5-6/wk) compared with the lowest intake group (≤1-2/wk; P = 0.004). In multivariable linear regression analyses, higher dietary intake of ω-3 PUFAs and ω-3 highly unsaturated fatty acids was significantly associated with decreased levels of ABCA1 DNA methylation (P = 0.001 and 0.005); whereas no significant associations were seen between intake of dietary saturated fatty acid, monounsaturated fatty acid, and ω-6 PUFAs and ABCA1 DNA methylation. CONCLUSION: Higher dietary fish and ω-3 PUFA intake were associated with lower ABCA1 DNA levels in a Japanese population. The present results may bring potential insights on biological mechanisms underlying the protective effects of dietary fish and ω-3 PUFA intakes on CVD.
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Authors | Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 81
Pg. 110951
(01 2021)
ISSN: 1873-1244 [Electronic] United States |
PMID | 33045487
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- ABCA1 protein, human
- ATP Binding Cassette Transporter 1
- Fatty Acids
- Fatty Acids, Omega-3
- Fatty Acids, Unsaturated
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Topics |
- ATP Binding Cassette Transporter 1
(genetics)
- Adult
- Cross-Sectional Studies
- DNA Methylation
- Diet
- Fatty Acids
- Fatty Acids, Omega-3
- Fatty Acids, Unsaturated
- Female
- Humans
- Leukocytes
- Male
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