Piceatannol mediated regulation of deregulated signaling pathways in different cancers: Tumbling of the ninepins of molecular oncology.

Abstract

With the recent technological advancements, a new golden era of natural products drug discovery has dawned. Increasingly it is being realized that structural modularity of many pharmacologically active products derived natural sources allows a building-block approach which can be exploited for analysis of regulation of deregulated oncogenic protein networks in different cancers. Piceatannol has been shown to effectively modulate JAK/STAT, Wnt/β-catenin, mTOR pathway in different cancers. In addition, certain hints have emerged which shed light on the regulation of microRNAs by piceatannol in some cancers. Regulation of deregulated oncogenic pathways by Piceatannol is gradually capturing attention and might be helpful in the multi-targeting of deregulated oncogenic networks in cancers.

• Authors: Sawera Nayyab, Humaira Naureen, Areesha Maryam, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Konysbayeva Kenzhekul Konysbayevna, Ammad Ahmad Farooqi
• Journal: Cellular and molecular biology (Noisy-le-Grand, France) (Cell Mol Biol (Noisy-le-grand)) Vol. 66 Issue 6 Pg. 157-163 (Sep 30 2020) ISSN: 1165-158X [Electronic] France
• PMID: 33040801 (Publication Type: Journal Article, Review)

Chemical References

• STAT Transcription Factors
• Stilbenes
• Wnt Proteins
• beta Catenin
• 3,3',4,5'-tetrahydroxystilbene
• Janus Kinases

Topics

• Animals
• Humans
• Janus Kinases (metabolism)
• Medical Oncology (methods)
• Neoplasms (drug therapy, metabolism)
• STAT Transcription Factors (metabolism)
• Signal Transduction (drug effects)
• Stilbenes (pharmacology, therapeutic use)
• Wnt Proteins (metabolism)
• beta Catenin (metabolism)