COVID-19: a risk factor for fatal outcomes in patients with comorbid cardiovascular disease.

Abstract

OBJECTIVES:

To evaluate the fatal impact of COVID-19 on patients with comorbid cardiovascular disease (CVD).

RESULTS:

Overall, the 28-day mortality of patients with comorbid CVD was 3.25 times of that of patients without comorbid CVD (40.63% vs 12.50%, P=0.011). Clinic symptoms on admission were similar for the two groups. However, patients with comorbid CVD had higher levels of Interleukin-10 (22.22% vs 0%, P=0.034), procalcitonin (22.6% vs 3.13%, P<0.001), high-sensitivity troponin I (20 pg/mL vs 16.05 pg/mL, P=0.019), and lactic dehydrogenase (437 U/L vs 310 U/L, P=0.015). In addition, patients with comorbid CVD experienced a high incidence of acute respiratory distress syndrome (59.38% vs 15.63%, P<0.001), and required more invasive mechanical ventilation (40.63% vs 12.50%, P=0.011). Methylprednisolone was found to improve the survival of patients without comorbid CVD (p = 0.05).

CONCLUSIONS:

Comorbid CVD resulted in a higher mortality rate for COVID-19 patients. Acute respiratory distress syndrome was the primary reason of death for COVID-19 patients with comorbid CVD, followed by acute myocardial infarction.

METHODS:

This retrospective study used propensity score matching to divide 64 COVID-19 patients into two groups with and without comorbid CVD. Clinic symptoms, laboratory features, treatments, and 28-day mortality were compared between the two groups.

• Authors: Hui Xu, Ling Ai, Chun Qiu, Xi Tan, Bo Jiao, Ailin Luo, Shusheng Li, Shangkun Liu, Li Yan
• Journal: Aging (Aging (Albany NY)) Vol. 12 Issue 19 Pg. 18866-18877 (Oct 09 2020) ISSN: 1945-4589 [Electronic] United States
• PMID: 33040051 (Publication Type: Journal Article)