Intravenous immunoglobulins (
IVIg) represent an established cornerstone for the
immunotherapy of chronic inflammatory demyelinating
polyneuropathy (
CIDP). Efficacy of
IVIg for
CIDP was proven in a large phase III trial. Yet, data on longer-term efficacy and effects in distinct subgroups are scarce. Our trial investigates the long-term efficacy of
IVIg treatment in
CIDP patients. In this observational real-world study, we retrospectively analyzed 49
CIDP patients receiving continuous
IVIg treatment with a mean initial dosage of 87 g (1 g/kg
body weight) every 4 weeks over a mean time of 45 months between 2010 and 2018. INCAT-Scores before the start of treatment and at the end of the observation period were compared. Over the observation period,
IVIg treatment led to a median improvement of one INCAT score point. Subgroup analyses revealed a more pronounced improvement of INCAT scores in female
CIDP patients, individuals with relapsing disease courses, patients with more pronounced motor impairment (higher initial INCAT scores) and in the cohort without need for concomitant other
immunotherapies. These data argue for sustained beneficial effects of longer-term
immunotherapy with
IVIg in
CIDP, particularly in females and relapsing disease forms with higher disease activity.