Pleural, pancreatic and prostatic involvement in IgG4-related disease mimicking pancreatic head malignancy.

Abstract

We describe the case of a gentleman with pleural thickening. On follow-up imaging, dilatation of the main pancreatic and common biliary ducts was noted and an initial diagnosis of pancreatic malignancy was made. During his preoperative workup for pancreatic head malignancy, a PET-CT was performed, which demonstrated increased uptake in the pancreas, in the pleura and in the prostate gland. This raised the possibility of immunoglobulin G4-related disease (IgG4-RD), which was effectively treated with oral steroids. IgG4-RD is a well-described cause of autoimmune pancreatitis but can affect other regions, including the pleura and prostate. It is essential that radiologists are aware of the imaging findings in IgG4-RD and can direct clinicians towards this important multisystem diagnosis.

• Authors: Robert W Foley, Stewart L Redman, Richard N Graham, Jaspal S Phull, Vidan Masani, Benjamin J Colleypriest, David Little
• Journal: BJR case reports (BJR Case Rep) Vol. 6 Issue 2 Pg. 20190110 (Sep 2020) ISSN: 2055-7159 [Electronic] England
• PMID: 33029374 (Publication Type: Case Reports)
• Copyright: © 2020 The Authors. Published by the British Institute of Radiology.