Effectiveness of Toothpaste Containing REFIX Technology against Dentin Hypersensitivity: A Randomized Clinical Study.

Abstract

AIM:

This clinical study aimed to evaluate the efficacy of a toothpaste containing a proprietary REFIX technology (Regenerador + Sensitive DentalClean, Rabbit Corp) against dentin hypersensitivity.

MATERIALS AND METHODS:

Fifty-three volunteers who fulfilled the inclusion criteria and signed the consent form were included. They were examined for dentin hypersensitivity. The participants received a 1-second blast of air, and the tooth sensitivity, from 0 to 10, was immediately evaluated using a visual analog scale (VAS). Then, the participants brushed their teeth with the multifunctional toothpaste, and dentin hypersensitivity was tested a second time using the same scale. The participants continued to use the toothpaste three times a day for 1 week, after which dentin hypersensitivity was recorded for the third time. Data were statistically analyzed using analysis of variance (ANOVA) and Tukey's test (α = 0.05).

RESULTS:

The mean patient age was 40 years, and 70% of the 53 subjects were female. There was a significant reduction in dentin hypersensitivity immediately after using the toothpaste and after 1 week. The baseline mean patient-reported pain score was severe (6.5 ± 2.4). Immediately after the first use of the toothpaste, the mean reported pain significantly decreased to mild pain (2.5 ± 2.5) (p < 0.05). After 1 week of consistent use of the toothpaste, the pain score reduced significantly (0.7 ± 1.2) (p < 0.05), and most participants reported no pain, demonstrating the effectiveness of the REFIX technology against dentin hypersensitivity.

CONCLUSION:

This clinical trial shows that the use of the phosphate-based desensitizing toothpaste containing REFIX technology significantly reduces dentin hypersensitivity after 1 week of consistent use.

CLINICAL SIGNIFICANCE:

The absence of pain, a desired clinical condition in patients with dentin hypersensitivity, was reached with the use of desensitizing toothpaste containing REFIX technology after 1 week of use. Such condition positively impacts quality of life, providing a healthier daily routine for patients.

• Authors: Fabiano V Vilhena, Mackeler R Polassi, Eloisa Ac Paloco, Roberta Cb Alonso, Ricardo D Guiraldo, Paulo Hp D'Alpino
• Journal: The journal of contemporary dental practice (J Contemp Dent Pract) Vol. 21 Issue 6 Pg. 609-614 (Jun 01 2020) ISSN: 1526-3711 [Electronic] India
• PMID: 33025927 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Dentin Desensitizing Agents
• Toothpastes
• Sodium Fluoride
• Arginine
• Calcium Carbonate
• Fluorides

Topics

• Arginine
• Calcium Carbonate
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (drug therapy, prevention & control)
• Double-Blind Method
• Female
• Fluorides
• Humans
• Quality of Life
• Sodium Fluoride
• Toothbrushing
• Toothpastes (therapeutic use)
• Treatment Outcome