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Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein.

AuthorsChan Yang, Xiaoyan Pan, Xinfeng Xu, Chen Cheng, Yuan Huang, Lin Li, Shibo Jiang, Wei Xu, Gengfu Xiao, Shuwen Liu
JournalSignal transduction and targeted therapy (Signal Transduct Target Ther) Vol. 5 Issue 1 Pg. 220 (10 06 2020) ISSN: 2059-3635 [Electronic] England
PMID33024075 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkenes
  • Antiviral Agents
  • Polyphenols
  • Protein Subunits
  • Receptors, Virus
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • salvianolic acid C
Topics
  • Alkenes (chemistry, pharmacology)
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Antiviral Agents (chemistry, pharmacology)
  • Betacoronavirus (drug effects, genetics, growth & development, metabolism)
  • Binding Sites
  • Biological Assay
  • COVID-19
  • Chlorocebus aethiops
  • Coronavirus Infections (drug therapy)
  • Drug Discovery
  • Gene Expression
  • HEK293 Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Docking Simulation
  • Pandemics
  • Peptidyl-Dipeptidase A (chemistry, genetics, metabolism)
  • Pneumonia, Viral (drug therapy)
  • Polyphenols (chemistry, pharmacology)
  • Protein Binding
  • Protein Conformation, alpha-Helical
  • Protein Interaction Domains and Motifs
  • Protein Subunits (antagonists & inhibitors, chemistry, genetics, metabolism)
  • Receptors, Virus (chemistry, genetics, metabolism)
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus (antagonists & inhibitors, chemistry, genetics, metabolism)
  • Vero Cells
  • Virus Internalization (drug effects)

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