Traditional
cancer diagnosis strategies are not considered by most people until the last resort, which delays many
cancer treatments leading to advanced stages.
Tumor marker sensors show great potential for detecting
cancer because of its cost-effective and harmless checking procedures. Normally, one
tumor marker is detected each time by using one type of sensor, but the accuracy to declare
cancer is not always satisfied.
Metal nanoclusters are ultra-small nanomaterials with low toxicity, distinct optical properties, catalytic activities, and cost-effective performance. Some
metal nanoclusters have been designed to detect more than one
tumor marker in a single step. The consideration of combined parameters using such facile sensing strategies has the potential to simplify the test procedure, and increase the diagnostic accuracy of early
cancer. Therefore, various sensing strategies for the multiplex detection of
tumor markers using
metal nanoclusters are summarized.