Abstract | STUDY OBJECTIVE: DESIGN: Double-blinded randomized placebo-controlled trial. SETTING: Labor and delivery triage room. PATIENTS: INTERVENTIONS: MEASUREMENTS: The primary outcome measured was intra- procedural pain. Secondary outcomes were intra-procedural anxiety, patient satisfaction, and procedure difficulty. MAIN RESULTS: Forty-eight patients were enrolled; 23 received nitrous oxide and 25 received oxygen. No difference was noted in mean pain scores ( nitrous oxide 5.5 ± 2.3, placebo 5.4 ± 2.7, [CI95% = -1.40, 1.51]; P = 0.943) or anxiety scores ( nitrous oxide 1.6 ± 2.0, placebo 1.2 ± 1.8, [CI95% = -0.74, 1.45]; P = 0.515). Procedural difficulty (1-10 scale, 1 = very easy, 10 = extremely difficult) was not different between groups ( nitrous oxide 6.1 ± 2.2, placebo 6.1 ± 3.2, [CI95% = -1.54, 1.66]; P = 0.944). There was a significant increase in the number of version attempts in the nitrous oxide group ( nitrous oxide 3.9 ± 1.9, placebo 2.8 ± 1.4, [CI95% = 0.05, 2]; P = 0.046). Patient satisfaction was significantly lower in the nitrous oxide group ( nitrous oxide 4.3 ± 4.0, placebo 6.9 ± 3.6, [CI95% = -4.93, -0.34]; P = 0.025). CONCLUSION:
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Authors | Lacey E Straube, Kristen L Fardelmann, Amy A Penwarden, Fei Chen, Elsje Harker, Benjamin F Redmon, Quefeng Li, Robert Strauss, Kathleen A Smith |
Journal | Journal of clinical anesthesia
(J Clin Anesth)
Vol. 68
Pg. 110073
(Feb 2021)
ISSN: 1873-4529 [Electronic] United States |
PMID | 33017784
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Analgesia
- Breech Presentation
- Female
- Humans
- Infant
- Nitrous Oxide
(adverse effects)
- Pain
- Pregnancy
- Treatment Outcome
- Version, Fetal
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