Abstract |
Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes ( MODS). Acute lung injury (ALI) is one of the most serious complications of SAP. However, the specific pathogenesis of SAP-associated ALI is not fully understood. Crosstalk and multi-mechanisms involving pancreatic necrosis, bacteremia, intestinal barrier failure, activation of inflammatory cascades and diffuse alveolar damage is the main reason for the unclear pathological mechanism of SAP-associated ALI. According to previous research on SAP-associated ALI in our laboratory and theories put forward by other scholars, we propose that the complex pattern of SAP-associated ALI is based on the "pancreas-intestine- inflammation/ endotoxin-lung (P-I-I/E-L) pathway". In this review, we mainly concentrated on the specific details of the "P-I-I/E-L pathway" and the potential treatments or preventive measures for SAP-associated ALI.
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Authors | Peng Ge, Yalan Luo, Chukwuemeka Samuel Okoye, Haiyang Chen, Jiayue Liu, Guixin Zhang, Caiming Xu, Hailong Chen |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 132
Pg. 110770
(Dec 2020)
ISSN: 1950-6007 [Electronic] France |
PMID | 33011613
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2020. Published by Elsevier Masson SAS. |
Chemical References |
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Topics |
- Acute Lung Injury
(etiology, physiopathology, prevention & control)
- Animals
- Endotoxins
(metabolism)
- Humans
- Intestines
(pathology)
- Multiple Organ Failure
(etiology, physiopathology)
- Pancreatitis
(complications, physiopathology)
- Pancreatitis, Acute Necrotizing
(etiology, pathology)
- Systemic Inflammatory Response Syndrome
(etiology, physiopathology)
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