Highlights from Studies in Cardiovascular Disease Prevention Presented at the Digital 2020 European Society of Cardiology Congress: Prevention Is Alive and Well.

Abstract

PURPOSE OF REVIEW:

The review highlights selected studies related to cardiovascular disease (CVD) prevention that were presented at the 2020 European Society of Cardiology (ESC) Congress-The Digital Experience.

RECENT FINDINGS:

The studies reviewed include clinical trials on novel RNA interference-based lipid-lowering therapies AKCEA-APOCIII-LRx and vupanorsen (AKCEA-ANGPTL3-LRx); the EVAPORATE trial assessing the effects of icosapent ethyl on coronary plaque volume progression; the LoDoCo2 trial evaluating the efficacy of low-dose colchicine in cardiovascular disease risk reduction among patients with chronic coronary artery disease; as well as the EMPEROR-Reduced trial evaluating cardiovascular and renal outcomes with empagliflozin in patients with heart failure and reduced ejection fraction. In addition, we review the BPLTTC analysis on blood pressure treatment across blood pressure levels and CVD status and discuss findings from the BRACE CORONA study that examined continuing versus suspending angiotensin-converting enzyme inhibitor or angiotensin receptor blockers in patients on these antihypertensive medications who were hospitalized with COVID-19 infection. The studies presented at the 2020 digital ESC Congress highlight the continuing advancements in the field of CVD prevention.

• Authors: Xiaoming Jia, Mahmoud Al Rifai, Aliza Hussain, Seth Martin, Anandita Agarwala, Salim S Virani
• Journal: Current atherosclerosis reports (Curr Atheroscler Rep) Vol. 22 Issue 12 Pg. 72 (10 03 2020) ISSN: 1534-6242 [Electronic] United States
• PMID: 33009957 (Publication Type: Journal Article, Review)

Chemical References

• AKCEA-APO(a)-LRx
• Benzhydryl Compounds
• Cardiovascular Agents
• Glucosides
• Lipid Regulating Agents
• Oligonucleotides
• eicosapentaenoic acid ethyl ester
• Eicosapentaenoic Acid
• empagliflozin

Topics

• Benzhydryl Compounds (pharmacology)
• Betacoronavirus (physiology)
• COVID-19
• Cardiology (methods, trends)
• Cardiovascular Agents (pharmacology)
• Cardiovascular Diseases (epidemiology, prevention & control)
• Clinical Trials as Topic
• Congresses as Topic
• Coronavirus Infections (epidemiology, therapy)
• Eicosapentaenoic Acid (analogs & derivatives, pharmacology)
• Europe
• Glucosides (pharmacology)
• Humans
• Lipid Regulating Agents (pharmacology)
• Oligonucleotides (pharmacology)
• Pandemics
• Pneumonia, Viral (epidemiology, therapy)
• SARS-CoV-2
• Societies, Medical
• Telecommunications