Efficacy of progesterone on threatened miscarriage: an updated meta-analysis of randomized trials.

Abstract

PURPOSE:

The efficacy of progesterone supplementation in the treatment of threatened miscarriage is controversial. This meta-analysis was to evaluate the correlation between progesterone and improving pregnancy outcomes in women with threatened miscarriage.

METHODS:

We searched PubMed, EMBASE, and the Cochrane Library for relevant randomized controlled trials (RCTs) to demonstrate the efficacy of progesterone on the threatened miscarriage pregnancy. The outcomes were miscarriage, preterm birth, and live birth.

RESULTS:

Nine RCTs comparing 4907 patients were included in this study. Compared with placebo or no treatment, progesterone supplementation had a relationship with a reduction in the rate of miscarriage [RR 0.70 95% Cl (0.52, 0.94)]. There was no significant difference between progesterone supplementation and placebo or no treatment in preterm birth [RR 0.87 95% Cl (0.52, 1.47) and live birth (RR 1.02 95% Cl (0.98, 1.07)].

CONCLUSION:

Progesterone supplementation did not significantly improve the incidence of preterm and live birth, so progesterone treatment of threatened miscarriage may be unhelpful.

• Authors: Yuying Yan, Zeping Chen, Ying Yang, Xinkuo Zheng, Meijuan Zou, Gang Cheng, Zhenting Yuan
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 303 Issue 1 Pg. 27-36 (01 2021) ISSN: 1432-0711 [Electronic] Germany
• PMID: 32989508 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Progesterone

Topics

• Abortion, Threatened (drug therapy)
• Adult
• Female
• Humans
• Live Birth
• Pregnancy
• Pregnancy Outcome
• Premature Birth (epidemiology)
• Progesterone (administration & dosage, therapeutic use)
• Randomized Controlled Trials as Topic