Abstract | PURPOSE: METHODS: Single-center, retrospective, observational case series of 50 eyes of 50 patients with MacTel2 and 50 eyes of 50 age-matched controls. RESULTS: Thirty-seven eyes in the MacTel2 group (74%) showed peripheral capillary nonperfusion or dropout, compared with 37 eyes in the control group (74%, P = 1.0). Morphologically, the MacTel2 group trended toward having a higher proportion of pruning-type capillary dropout (44%) compared with controls (28%), but this was not statistically significant (P = 0.12). Patients with MacTel2 had a higher incidence of microaneurysms compared with controls (MacTel2 56%; controls 42%; P = 0.048), independent of age or systemic risk factors. There was no difference in the incidence of venous-venous shunts (MacTel2 10%; controls 10%; P = 1.0), arteriovenous shunts (MacTel2 14%; controls 18%; P = 0.60), venous tortuosity (MacTel2 60%; controls 66%; P = 0.58), or arterial tortuosity (MacTel2 54%; controls 68%; P = 0.20), which was mild in most cases. CONCLUSION: We note a high incidence of peripheral vascular and retinal findings in both patients with MacTel2 and age-matched controls, using widefield fluorescein angiography. Patients with MacTel2 had significantly more microaneurysms, independent of age or other systemic risk factors.
|
Authors | Stavros N Moysidis, Nicole Koulisis, Prethy Rao, Viren K Govindaraju, Samuel Gamsky, Tamer H Mahmoud, Sandeep Randhawa, Lisa J Faia, Jeremy D Wolfe, Kimberly A Drenser, Alan J Ruby, Bruce R Garretson, Tarek S Hassan, George A Williams, Michael T Trese, Antonio Capone Jr |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 41
Issue 3
Pg. 480-486
(Mar 01 2021)
ISSN: 1539-2864 [Electronic] United States |
PMID | 32969983
(Publication Type: Journal Article, Observational Study)
|
Topics |
- Aged
- Capillaries
(diagnostic imaging)
- Female
- Fluorescein Angiography
(methods)
- Humans
- Macula Lutea
(blood supply, diagnostic imaging)
- Male
- Retinal Telangiectasis
(diagnosis)
- Retinal Vessels
(diagnostic imaging)
- Retrospective Studies
- Tomography, Optical Coherence
|