Breaking β Cell Tolerance After 100 Years of Life: Intratumoral Immunotherapy-Induced Diabetes Mellitus.

Abstract

Cancer immunotherapies are changing the landscape of cancer care. Intratumoral talimogene iaherparepvec (T-VEC), an oncolytic viral vaccine, has been approved for treatment of unresectable melanoma with minimal toxicity. We describe the first case of a centenarian who developed autoimmune diabetes while on T-VEC immunotherapy. The patient's high titer of glutamic acid decarboxylase 65 autoantibodies as well as insulin deficiency are consistent with autoimmune diabetes. Autoimmune diabetes has previously been seen following immune checkpoint inhibitor use; however, it has never been reported with T-VEC. This case highlights that autoimmune diabetes can be a rare but morbid complication of intratumoral T-VEC immunotherapy and can occur in the ultra-elderly.

• Authors: Zoe Quandt, Catherine Coupe, Mark Anderson, Alexander Uihlein, Arabella Young
• Journal: Journal of the Endocrine Society (J Endocr Soc) Vol. 4 Issue 10 Pg. bvaa114 (Oct 01 2020) ISSN: 2472-1972 [Electronic] United States
• PMID: 32964173 (Publication Type: Case Reports)
• Copyright: © Endocrine Society 2020.