Effects of caloric restriction on retinal aging and neurodegeneration.

Abstract

Glaucoma is the most common neurodegenerative cause of irreversible blindness worldwide. Restricted caloric regimens are an attractive approach for delaying the progression of neurodegenerative diseases. Here we review the current literature on the effects of caloric restriction on retinal neurons, under physiological and pathological conditions. We focused on autophagy as one of the mechanisms modulated by restricted caloric regimens and involved in the death of retinal ganglion cells (RGCs) over the course of glaucoma.

• Authors: Annagrazia Adornetto, Luigi Antonio Morrone, Andrea Satriano, Maria Luisa Laganà, Ester Licastro, Carlo Nucci, Maria Tiziana Corasaniti, Paolo Tonin, Giacinto Bagetta, Rossella Russo
• Journal: Progress in brain research (Prog Brain Res) Vol. 256 Issue 1 Pg. 189-207 ( 2020) ISSN: 1875-7855 [Electronic] Netherlands
• PMID: 32958212 (Publication Type: Journal Article, Review)
• Copyright: © 2020 Elsevier B.V. All rights reserved.

Topics

• Aging (pathology)
• Animals
• Autophagy
• Caloric Restriction
• Glaucoma (diet therapy, pathology)
• Humans
• Neurodegenerative Diseases (diet therapy, pathology)
• Retinal Neurons (pathology, physiology)