Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia - a distinct subtype with favorable prognosis.

Abstract

The recurring translocation t(1;19) (q23;p13) with TCF3-PBX1 rearrangements are uncommon in adult acute lymphoblastic leukemia (ALL), and their prognostic impact remains to be described in the era of modern chemotherapies. We investigated 427 adult patients with newly diagnosed pre-B ALL, 16 (4%) had t(1;19)(q23;p13) at diagnosis. All 16 patients achieved complete remission after induction with intensive chemotherapy, and with a median of 7-year follow-up, 2 relapsed. The 5-year cumulative incidence of relapse and overall survival rates were 14% and 82%, respectively. Our analysis showed that adult patients with t(1;19)(q23;p13) positive ALL had favorable prognosis with intensive chemotherapy regimens.

• Authors: Musa Yilmaz, Hagop M Kantarjian, Gokce Toruner, C Cameron Yin, Rashmi Kanagal-Shamanna, Jorge E Cortes, Ghayyas Issa, Nicholas J Short, Joseph D Khoury, Guillermo Garcia-Manero, Farhad Ravandi, Tapan Kadia, Marina Konopleva, William G Wierda, Nitin Jain, Zeev Estrov, Koji Sasaki, Sherry Pierce, Susan M O'Brien, Elias J Jabbour
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 62 Issue 1 Pg. 224-228 (01 2021) ISSN: 1029-2403 [Electronic] United States
• PMID: 32955970 (Publication Type: Journal Article)

Chemical References

• Oncogene Proteins, Fusion

Topics

• Adult
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 19 (genetics)
• Humans
• Oncogene Proteins, Fusion (genetics)
• Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (genetics)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis, drug therapy, epidemiology)
• Prognosis
• Translocation, Genetic