Efficacy of an orally administered combination of Lactobacillus paracasei LC11, cranberry and D-mannose for the prevention of uncomplicated, recurrent urinary tract infections in women.

Abstract

BACKGROUND:

Most women experience a urinary tract infection (UTI) at least once in their lifetime. The present study determined the efficacy and safety of a combination of Lactobacillus paracasei LC11, cranberry and D-mannose (Lactoflorene Cist®) in the prophylaxis of recurrent uncomplicated UTIs in premenopausal women.

METHODS:

This single-centre study enrolled premenopausal women aged 18-50 years with an acute UTI and a history of recurrent uncomplicated UTIs. Patients were first treated with fosfomycin (3 g once a day for 2 days) to eliminate any underlying infection, followed by treatment with Lactoflorene Cist® once a day for 10 days/month for 90 days (Group 1), Lactoflorene Cist® once daily for 90 days (Group 2) or no treatment (Group 3; control). The main study endpoint was the rate of UTI recurrence during the study period. Any adverse events with treatment were also recorded.

RESULTS:

A total of 55 women (mean age 39.3 years; range: 20-46) were enrolled in the study. A significantly higher proportion of patients in the control group experienced UTIs during the study period compared with the two treatment groups (52.9% vs 16.0% in Group 1 and 15.5% in group 2; p < 0.01). Similarly, a higher proportion of patients in Group 1 (65.8%) and Group 2 (68.7%) remained UTI-free during the study versus the control group. No adverse events were reported in the treated patients.

CONCLUSION:

Prophylactic treatment with Lactoflorene Cist® was effective and safe in the management of recurrent uncomplicated UTIs in premenopausal women.

• Authors: Filippo Murina, Franco Vicariotto, Chiara Lubrano
• Journal: Urologia (Urologia) Vol. 88 Issue 1 Pg. 64-68 (Feb 2021) ISSN: 1724-6075 [Electronic] United States
• PMID: 32954992 (Publication Type: Journal Article)

Chemical References

• Mannose

Topics

• Acute Disease
• Adult
• Female
• Humans
• Lacticaseibacillus paracasei
• Mannose (therapeutic use)
• Middle Aged
• Phytotherapy
• Recurrence
• Urinary Tract Infections (drug therapy, prevention & control)
• Vaccinium macrocarpon
• Young Adult