Abstract | BACKGROUND:
Hemoglobin (Hb), white blood cell (WBC), and polymorphonuclear neutrophil (PMN) blood counts may be correlated with outcomes in patients with locally advanced cervical cancer. METHODS: Hb, WBC, and PMN counts were measured at diagnosis and during concomitant cisplatin-based chemoradiotherapy (CCRT) in a retrospective sample of 103 patients between 2010 and 2017. Red blood cell (RBC) transfusions were also recorded. The associations between hematological variables and patient overall survival (OS) and recurrence-free survival (RFS) were assessed by Cox regression models. RESULTS: The 3-year OS and RFS rates were 81.4% and 76.8%, respectively. In addition to tumor size and smoking, OS and RFS were found to be significantly associated with changes in WBC and PMN counts from the first to the last cisplatin cycle. Hb count throughout the treatment and RBC transfusions were not predictive of outcome. CONCLUSIONS: This study found no association between Hb count or RBC transfusions and outcome. The daily practice of maintaining the Hb count above 12 g/dL during CCRT should be weighed against the potential risks of transfusions. Drops in WBC and PMN counts during treatment positively impacted OS and RFS and could, therefore, serve as biomarkers during CCRT to adapt the follow-up and consider the need for adjuvant systemic treatments.
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Authors | Christine Gennigens, Marjolein De Cuypere, Laurence Seidel, Johanne Hermesse, Annelore Barbeaux, Frédéric Forget, Adelin Albert, Guy Jerusalem, Frédéric Kridelka |
Journal | Cancer medicine
(Cancer Med)
Vol. 9
Issue 22
Pg. 8432-8443
(11 2020)
ISSN: 2045-7634 [Electronic] United States |
PMID | 32954675
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
Chemical References |
- Antineoplastic Agents
- Biomarkers
- Hemoglobins
- Cisplatin
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Topics |
- Adenocarcinoma
(blood, diagnostic imaging, mortality, therapy)
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Biomarkers
(blood)
- Carcinoma, Squamous Cell
(blood, diagnostic imaging, mortality, therapy)
- Chemoradiotherapy
(adverse effects, mortality)
- Cisplatin
(adverse effects, therapeutic use)
- Disease Progression
- Dose Fractionation, Radiation
- Erythrocyte Transfusion
- Female
- Hemoglobins
(metabolism)
- Humans
- Leukocytes
- Middle Aged
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Neutrophils
- Radiotherapy, Conformal
(adverse effects, mortality)
- Radiotherapy, Intensity-Modulated
- Retrospective Studies
- Time Factors
- Treatment Outcome
- Uterine Cervical Neoplasms
(blood, diagnostic imaging, mortality, therapy)
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