Formation of atherosclerotic lesions is independent of eosinophils in male mice.

Abstract

BACKGROUND AND AIMS:

Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a potential role of type 2 immunity in atherogenesis. However, the involvement of individual type 2 immune cell subsets involved in this process has been incompletely defined. We therefore sought to determine the role of eosinophils during LDL oxidation and the pathogenesis of this disease.

METHODS:

Using eosinophil-deficient dblGATA1 mice, we studied the role of eosinophils in two established mouse models of atherosclerosis.

RESULTS:

These experiments revealed that the presence of eosinophils did neither affect biomarkers of LDL oxidation nor atherosclerotic lesion development.

CONCLUSIONS:

The obtained results show that LDL oxidation and development of atherosclerosis are largely independent of eosinophils or eosinophil-mediated LDL oxidation.

• Authors: Katharina Hofheinz, Fabian Seibert, Jochen A Ackermann, Barbara Dietel, Miyuki Tauchi, Maria Oszvar-Kozma, Hartmut Kühn, Georg Schett, Christoph J Binder, Gerhard Krönke
• Journal: Atherosclerosis (Atherosclerosis) Vol. 311 Pg. 67-72 (10 2020) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 32947200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Lipoproteins, LDL

Topics

• Animals
• Arteriosclerosis
• Atherosclerosis
• Biomarkers
• Eosinophils
• Lipoproteins, LDL (metabolism)
• Male
• Mice
• Oxidation-Reduction