Mitochondria membrane transformations in colon and prostate cancer and their biological implications.

Abstract

Mitochondria have emerged as important determinants in cancer progression and malignancy. However, the role of mitochondrial membranes in cancer onset and progression has not been thoroughly investigated. This study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells in comparison to normal mitochondria, and possible therapeutic implications of these membrane changes. Specifically, isolation of cell mitochondria and preparation of inverted sub-mitochondrial particles (SMPs) illuminated significant cancer-induced modulations of membrane lipid compositions, fluidity, and activity of cytochrome c oxidase, one of the key mitochondrial enzymes. The experimental data further show that cancer-associated membrane transformations may account for mitochondria targeting by betulinic acid and resveratrol, known anti-cancer molecules. Overall, this study probes the relationship between cancer and mitochondrial membrane transformations, underlying a potential therapeutic significance for mitochondrial membrane targeting in cancer.

• Authors: Shani Ben Zichri, Sofiya Kolusheva, Alexander I Shames, Elina Abaev Schneiderman, Juan L Poggio, David E Stein, Elena Doubijensky, Dan Levy, Zulfiya Orynbayeva, Raz Jelinek
• Journal: Biochimica et biophysica acta. Biomembranes (Biochim Biophys Acta Biomembr) Vol. 1863 Issue 1 Pg. 183471 (01 01 2021) ISSN: 1879-2642 [Electronic] Netherlands
• PMID: 32931774 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020. Published by Elsevier B.V.

Chemical References

• Membrane Lipids
• Mitochondrial Proteins
• Neoplasm Proteins

Topics

• Colonic Neoplasms (metabolism, pathology)
• HCT116 Cells
• Humans
• Male
• Membrane Lipids (metabolism)
• Mitochondria (metabolism, pathology)
• Mitochondrial Membranes (metabolism, pathology)
• Mitochondrial Proteins (metabolism)
• Neoplasm Proteins (metabolism)
• Prostatic Neoplasms (metabolism, pathology)