Patterns of cardiac dysfunction after carbon monoxide poisoning.

Abstract

Objective:

To describe the structural sequelae of carbon monoxide (CO) poisoning on the heart assessed using stress cardiac MRI (CMR). CO poisoning is common. While acute cardiac injury is frequent among survivors, the mid- and long-term effects of CO on the myocardium are unclear.

Methods:

CMR studies performed between the years 2005 and 2014 for a primary diagnosis of CO poisoning at a tertiary care center were reviewed by an experienced cardiologist. Variables of interest were compared between patients with normal and abnormal studies to identify factors associated with cardiac dysfunction.

Results:

Eighty-eight patients underwent stress CMR, age 34 years (range 11-70); 49% were male, 74 had acute poisoning and 14 had chronic poisoning (CO exposure for longer than 24 hours). Time from CO poisoning to imaging was 24 months (1 day-120 months). Patients were stratified into four categories, which included those with acute poisoning imaged: ≤12 months; 12-60 months; >60 months from the event; and those with chronic poisoning. Overall, 26 studies (30%) were abnormal. The most common findings were: left ventricular systolic dysfunction in 14 patients, right ventricular systolic dysfunction in nine, and LV dilatation in six. Abnormalities were mild in most cases and were equally prevalent in all four patient categories. Dyspnea at the time of follow-up was more frequent among those with abnormal studies.

Conclusion:

Mild alterations in ventricular structure and function are frequent in survivors of CO poisoning. Myocardial scarring is rare, suggesting that acute hypoxic injury may not fully explain these abnormalities.

• Authors: Miguel Alvarez Villela, Omar Wever-Pinzon, Mona Parikh, Kayla Deru, Joseph B Muhlestein, Jeffrey L Anderson, Lindell K Weaver
• Journal: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc (Undersea Hyperb Med) 2020 Third Quarter Vol. 47 Issue 3 Pg. 477-485 ISSN: 1066-2936 [Print] United States
• PMID: 32931676 (Publication Type: Journal Article)
• Copyright: Copyright© Undersea and Hyperbaric Medical Society.

Chemical References

• Troponin I
• Carboxyhemoglobin

Topics

• Adolescent
• Adult
• Aged
• Carbon Monoxide Poisoning (blood, complications)
• Carboxyhemoglobin (analysis)
• Cardiomyopathies (diagnostic imaging, etiology)
• Child
• Echocardiography
• Female
• Heart (diagnostic imaging)
• Heart Diseases (blood, diagnostic imaging, etiology)
• Heart Function Tests
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Statistics, Nonparametric
• Troponin I (blood)
• Ventricular Dysfunction, Left (diagnosis)
• Ventricular Dysfunction, Right (diagnosis)
• Young Adult