Association of triglyceride to high density lipoprotein ratio with global cardiac microcalcification to evaluate subclinical coronary atherosclerosis in non-diabetic individuals.

Abstract

OBJECTIVE:

Triglycerides (TG) to high density lipoprotein (HDL) ratio has been proposed as a marker of insulin resistance and atherosclerosis. We hypothesize that TG/HDL ratio correlates positively with global cardiac microcalcification as assessed by NaF-PET/CT as a surrogate marker for coronary atherosclerosis in healthy non-diabetic individuals.

METHOD:

We identified 68 healthy, non-diabetic individuals (age 41.7 ± 13.5 years; 35/33 female/male) from the CAMONA trial. All underwent PET/CT imaging 90 minutes after NaF injection (2.2 Mbq/Kg). Global cardiac average SUVmean (aSUVmean) was calculated by a trained physician for each individual. Fasting plasma lipid profile (total cholesterol (TC), low-density lipoprotein (LDL), HDL, and TG) and fasting plasma glucose were recorded. TG/HDL ratio was calculated for every individual. Univariate and multivariate linear regression models were used to assess the association between TG/HDL ratio and global cardiac aSUVmean.

RESULT:

On univariate analysis, there was a positive linear association of TG/HDL ratio and global cardiac aSUVmean (r=0.244, B=0.047, P=0.045). On multivariate analysis adjusted for age, gender, systolic blood pressure, diastolic blood pressure, smoking status, total cholesterol, low-density lipoprotein, and fasting plasma glucose, TG/HDL ratio was found to be independently associated with global cardiac aSUVmean (B=0.060, 95% CI: 0.007-0.114, P=0.027).

CONCLUSION:

There was a positive correlation between TG/HDL ratio with global cardiac microcalcification assessed by NaF-PET/CT imaging.

• Authors: Shivaraj Patil, Chaitanya Rojulpote, Karthik Gonuguntla, Pranav Karambelkar, Abhijit Bhattaru, William Y Raynor, Austin J Borja, Kiranmayi Vuthaluru, Vincent Zhang, Thomas J Werner, Oke Gerke, Poul Flemming Høilund-Carlsen, Abass Alavi
• Journal: American journal of cardiovascular disease (Am J Cardiovasc Dis) Vol. 10 Issue 3 Pg. 241-246 ( 2020) ISSN: 2160-200X [Print] United States
• PMID: 32923106 (Publication Type: Journal Article)
• Copyright: AJCD Copyright © 2020.