BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer.

Abstract

BACKGROUND:

Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.

OBJECTIVE:

The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.

METHODS:

QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.

RESULTS:

BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.

CONCLUSION:

LncRNA BC032913 may be considered as an impressive therapeutic target for GC.

• Authors: Shiva Behzadi, Behzad Baradaran, Mohammad Ali Hosseinpourfeizi, Narges Dastmalchi, Ali Rajabi, Milad Asadi, Reza Safaralizadeh
• Journal: Journal of gastrointestinal cancer (J Gastrointest Cancer) Vol. 52 Issue 3 Pg. 928-931 (Sep 2021) ISSN: 1941-6636 [Electronic] United States
• PMID: 32914372 (Publication Type: Journal Article)
• Copyright: © 2020. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• RNA, Long Noncoding
• BCO1 protein, human
• beta-Carotene 15,15'-Monooxygenase

Topics

• Down-Regulation
• Humans
• RNA, Long Noncoding (genetics)
• Stomach Neoplasms (genetics)
• beta-Carotene 15,15'-Monooxygenase (genetics)