Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report.

Abstract

BACKGROUND:

This case report presents a case of a patient with global cerebral infarction of uncertain etiology following an emergency surgery for acute type A aortic dissection. As a result, factor XII deficiency was revealed postoperatively. To date, there have been several reports of cardiovascular surgery in patients with factor XII deficiency. However, all previous reports were of patients whose factor XII deficiency had been detected preoperatively; therefore, before this, there had been no reports of complications associated with factor XII deficiency following cardiovascular surgery.

CASE PRESENTATION:

We report a case of emergency aortic arch replacement surgery for acute type A aortic dissection in a 57-year-old Japanese man. A blood test prior to the surgery showed coagulopathy, a platelet count of 117 × 109/L, a prothrombin time-international normalized ratio of 1.78, an activated partial thromboplastin time of 69.7 seconds, and fibrinogen < 50 mg/dl. A smaller-than-usual dose of heparin (8000 IU) was administered because the patient's activated clotting time was extremely prolonged (> 999 seconds). After the heparin administration, the activated clotting time, measured every 30-60 minutes, remained unchanged (> 999 seconds); therefore, additional heparin was not administered during the surgery, and there was no clinical problem during cardiopulmonary bypass. However, a diagnosis of global cerebral infarction was made on the first postoperative day. An additional blood coagulation test performed on postoperative day 9 revealed factor XII deficiency (8.0%). Regarding the reason that global cerebral infarction occurred in the present case, two reasons were considered: One was factor XII deficiency itself, and the other was low-dose heparin administration during the cardiopulmonary bypass due to excessively prolonged activated clotting time caused by factor XII deficiency.

CONCLUSIONS:

Factor XII deficiency should be considered in patients with prolonged activated clotting time and spontaneous thrombosis in vascular surgeries. Moreover, the present case emphasizes that management of heparin during cardiopulmonary bypass should not be performed on the basis of activated clotting time monitoring alone, especially in a case with prolonged activated clotting time.

• Authors: Keisuke Yoshida, Shiori Tanaka, Yuki Sato, Kazuhiro Watanabe, Kenichi Muramatsu, Masahiro Murakawa
• Journal: Journal of medical case reports (J Med Case Rep) Vol. 14 Issue 1 Pg. 150 (Sep 11 2020) ISSN: 1752-1947 [Electronic] England
• PMID: 32912328 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Heparin

Topics

• Anticoagulants
• Aorta, Thoracic (diagnostic imaging, surgery)
• Cerebral Infarction (etiology)
• Factor XII Deficiency
• Heparin
• Humans
• Male
• Middle Aged
• Partial Thromboplastin Time