Clinical significance of a microRNA signature for the identification and predicting prognosis in colorectal cancers with mucinous differentiation.

Abstract	Accumulating evidence supports the fact that the mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative of a particular CRC subtype with distinct clinical and molecular features. In addition, the prognostic significance of the mucinous carcinoma (MC) subtype remains poorly understood and biomarkers have been barely explored in this disease. Herein, we have performed a systematic and comprehensive analysis in MCs and non-MCs and identified a panel of microRNAs (miRNAs) that are differentially expressed between these two subtypes of CRC. Next, we interrogated their clinical significance and demonstrated their robust diagnostic and prognostic clinical ability in CRCs with mucinous differentiation. Finally, we established an integrative risk-assessment model by combining the miRNA-based risk scores together with TNM staging, which was a superior predictor of prognosis in mucinous CRC patients. Collectively, we report a novel miRNA biomarker panel for the identification and predicting survival in CRC patients with mucinous differentiation.
Authors	Juan Ruiz-Bañobre, Roshni Roy, Miren Alustiza Fernández, Óscar Murcia, Rodrigo Jover, Miguel Pera, Francesc Balaguer, Rafael López-López, Ajay Goel
Journal	Carcinogenesis (Carcinogenesis) Vol. 41 Issue 11 Pg. 1498-1506 (11 13 2020) ISSN: 1460-2180 [Electronic] England
PMID	32911537 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Copyright	© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].
Chemical References	Biomarkers, Tumor MicroRNAs
Topics	Adenocarcinoma, Mucinous (genetics, pathology) Aged Biomarkers, Tumor (genetics) Cell Differentiation Colorectal Neoplasms (genetics, pathology) Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Male MicroRNAs (genetics) Prognosis Retrospective Studies Survival Rate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!