Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient.

Abstract	Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.
Authors	Abuzar Ali Asif, Moni Roy, Sharjeel Ahmad
Journal	BMJ case reports (BMJ Case Rep) Vol. 13 Issue 9 (Sep 08 2020) ISSN: 1757-790X [Electronic] England
PMID	32907868 (Publication Type: Case Reports, Journal Article, Review)
Copyright	© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Chemical References	Anti-Bacterial Agents DNA, Bacterial
Topics	Aged Anti-Bacterial Agents (pharmacology, therapeutic use) Arthritis, Infectious (diagnosis, microbiology, therapy) Arthroscopy DNA, Bacterial (isolation & purification) Debridement Drug Resistance, Bacterial Drug Therapy, Combination Female High-Throughput Nucleotide Sequencing Humans Knee Joint (diagnostic imaging, microbiology, surgery) Magnetic Resonance Imaging Meniscectomy Osteoarthritis, Knee (diagnosis, microbiology, therapy) Polymerase Chain Reaction Sequence Analysis, DNA Severity of Illness Index Synovectomy Treatment Outcome Ureaplasma (drug effects, genetics, isolation & purification) Ureaplasma Infections (diagnosis, microbiology, therapy)

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