Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice.
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| Abstract |
Despite the fact that the majority of people in tuberculosis (TB)-endemic areas are vaccinated with the Bacillus Calmette-Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis-specific (or "non-BCG") subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis-specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis-specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design.
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| Authors | Claus Aagaard, Niels Peter Hell Knudsen, Iben Sohn, Angelo A Izzo, Hongmin Kim, Emma Holsey Kristiansen, Thomas Lindenstrøm, Else Marie Agger, Michael Rasmussen, Sung Jae Shin, Ida Rosenkrands, Peter Andersen, Rasmus Mortensen |
| Journal | Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 205 Issue 8 Pg. 2146-2155 (10 15 2020) ISSN: 1550-6606 [Electronic] United States |
| PMID | 32887748 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2020 by The American Association of Immunologists, Inc. |
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