Abstract |
Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell ( CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45med+ mononuclear cells expressing CD34+, CD133+, CXCR4+ ( chemokine [C-X-C motif] receptor 4), and VEGF2R+ ( vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low (<median) hematopoietic CPCs (CD34+, CD34+/CD133+, and CD34+/CXCR4+) were at an increased risk of cardiovascular death or myocardial infarction events (hazard ratios: 1.75 to 1.80) during 3.5-year follow-up, while those with RI and high CPCs (>median) were at a similar risk as those without RI.
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Authors | Anurag Mehta, Ayman S Tahhan, Chang Liu, Devinder S Dhindsa, Aditi Nayak, Ananya Hooda, Kasra Moazzami, Shabatun J Islam, Steven C Rogers, Zakaria Almuwaqqat, Ali Mokhtari, Iraj Hesaroieh, Yi-An Ko, Edmund K Waller, Arshed A Quyyumi |
Journal | JACC. Basic to translational science
(JACC Basic Transl Sci)
Vol. 5
Issue 8
Pg. 770-782
(Aug 2020)
ISSN: 2452-302X [Electronic] United States |
PMID | 32875168
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. |