Abstract | INTRODUCTION: The global epidemic of diabetes has led to an epidemic of diabetes complications. Diabetic neuropathy is the most common microvascular complication, of which diabetic peripheral neuropathy ( DPN) and autonomic neuropathy (AN) are the most prevalent, affecting ~50% of patients. DPN results in pain with a poor quality of life and a loss of sensation with an increased risk of foot ulceration. Autonomic neuropathy can cause significant morbidity in a minority and is associated with increased mortality. The cornerstone of treatment to prevent or limit the progression of DPN/AN is multifactorial risk factor modification including treatment of glycemia, lipids and blood pressure. Whilst, there are no FDA-approved disease-modifying therapies, there are a number of therapies to relieve symptoms in DPN and AN. AREAS COVERED: EXPERT OPINION: The FDA-approved Pregabalin and Duloxetine over 25 years ago and Tapentadol, 6 years ago for painful diabetic neuropathy. There are currently no FDA-approved disease-modifying treatments for diabetic neuropathy which has been attributed to inappropriate models of the disease with limited translational capacity and major limitations of trial designs and endpoints in clinical trials.
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Authors | Shazli Azmi, Uazman Alam, Jamie Burgess, Rayaz A Malik |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 22
Issue 1
Pg. 55-68
(Jan 2021)
ISSN: 1744-7666 [Electronic] England |
PMID | 32866410
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Diabetic Neuropathies
(drug therapy)
- Humans
- Pain
(etiology)
- Quality of Life
- Risk Factors
- Tapentadol
(therapeutic use)
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