Improved conjunctival microcirculation in diabetic retinopathy patients with MTHFR polymorphisms after Ocufolin™ Administration.

Abstract

PURPOSE:

To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients.

METHODS:

Eight D + PM patients received Ocufolin™ for six months (6 M). Bulbar conjunctival microvasculature and microcirculation metrics, including vessel diameter (D), axial blood flow velocity (Va), cross-sectional blood flow velocity (Vs), flow rate (Q), and vessel density (VD, Dbox), were measured at baseline, 4 M, and 6 M.

RESULTS:

The mean age was 54 ± 7 years. No significant demographic differences were found. Conjunctival microcirculation, measured as Va, Vs, and Q was significantly increased at 4 M and 6 M, compared to baseline. Va was 0.44 ± 0.10 mm/s, 0.58 ± 0.13 mm/s, 0.59 ± 0.13 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.01). Similarly, Vs was 0.31 ± 0.07 mm/s, 0.40 ± 0.09 mm/s, 0.41 ± 0.09 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). Q was 107.8 ± 49.4 pl/s, 178.0 ± 125.8 pl/s, 163.3 ± 85.8 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). The VD at 6 M was significantly higher than that at baseline (P = 0.017). Changes of D were positively correlated with changes of Va, Q, and VD. Effects of MTHFR and haptoglobin polymorphisms on the improvements of conjunctival microcirculation and microvasculature were found.

CONCLUSIONS:

Ocufolin™ supplementation improves conjunctival microcirculation in patients with diabetic retinopathy and common folate polymorphisms.

• Authors: Zhiping Liu, Hong Jiang, Justin H Townsend, Jianhua Wang
• Journal: Microvascular research (Microvasc Res) Vol. 132 Pg. 104066 (11 2020) ISSN: 1095-9319 [Electronic] United States
• PMID: 32860770 (Publication Type: Clinical Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Ocufolin
• MTHFR protein, human
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Aged
• Blood Flow Velocity
• Conjunctiva (blood supply)
• Diabetic Retinopathy (diagnosis, drug therapy, genetics, physiopathology)
• Dietary Supplements (adverse effects)
• Female
• Humans
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Microcirculation (drug effects)
• Middle Aged
• Polymorphism, Single Nucleotide
• Prospective Studies
• Recovery of Function
• Regional Blood Flow
• Time Factors
• Treatment Outcome