Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three-way randomized triple-blind cross-over trial.

Abstract

BACKGROUND:

This study aimed to compare the effects of sesame (SO), canola (CO), and sesame-canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes.

METHODS:

In this randomized, triple-blind, three-way, cross-over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), insulin sensitivity (HOMA2-%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods.

RESULTS:

Ninety-two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2-%S (p < 0.05). SO and SCO led to favourable changes in HOMA2-IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2-%B (p < 0.05). The sex-stratified analysis revealed that FSI and HOMA2-IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma-glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058).

CONCLUSIONS:

SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).

• Authors: Hamidreza Raeisi-Dehkordi, Mojgan Amiri, Alireza Zimorovat, Fatemeh Moghtaderi, Sadegh Zarei, Scott C Forbes, Amin Salehi-Abargouei
• Journal: Diabetes/metabolism research and reviews (Diabetes Metab Res Rev) Vol. 37 Issue 5 Pg. e3399 (07 2021) ISSN: 1520-7560 [Electronic] England
• PMID: 32860716 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 John Wiley & Sons Ltd.

Chemical References

• Rapeseed Oil
• Sesame Oil

Topics

• Cross-Over Studies
• Diabetes Mellitus, Type 2 (drug therapy)
• Female
• Glycemic Control
• Humans
• Insulin Resistance
• Liver
• Male
• Rapeseed Oil
• Sesame Oil
• Sesamum