QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report.

Abstract

Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes.

• Authors: Zain Ali, Mariya Khan, Waqas Ullah, Atsoufui A Kpehor, Muhammad Arslan Cheema
• Journal: Journal of community hospital internal medicine perspectives (J Community Hosp Intern Med Perspect) Vol. 10 Issue 2 Pg. 151-153 (May 21 2020) ISSN: 2000-9666 [Print] United States
• PMID: 32850053 (Publication Type: Case Reports)
• Copyright: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center.