Abstract | BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. METHODS: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios ( ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian. RESULTS: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian. CONCLUSION: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.
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Authors | Peng-Bo Wu, Rao Qian, Chai Hong, Yi-Tian Guo, Yuan-Jie Yu, Guo Zhang, Shi-Yun Tan |
Journal | Medicine
(Medicine (Baltimore))
Vol. 99
Issue 34
Pg. e19756
(Aug 21 2020)
ISSN: 1536-5964 [Electronic] United States |
PMID | 32846747
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
- PTGER4 protein, human
- Receptors, Prostaglandin E, EP4 Subtype
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Topics |
- Genetic Predisposition to Disease
- Humans
- Inflammatory Bowel Diseases
(genetics)
- Polymorphism, Single Nucleotide
- Receptors, Prostaglandin E, EP4 Subtype
(genetics)
- White People
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