Abstract | BACKGROUND/PURPOSE: METHODS: In this post-hoc analysis, microbiological data for subjects with conjunctivitis due to one or more than one bacterial species in three previous studies (two vehicle-, one active-controlled) of besifloxacin were extracted. Bacterial species identified at baseline were deemed causative if their colony count equaled or exceeded species-specific prespecified threshold criteria. In subjects with polybacterial infections, the fold-increase over threshold was used to rank order the contribution of individual species. Baseline pathogens and their minimum inhibitory concentrations (MICs) for common ophthalmic antibiotics were compared by infection type, as were microbial eradication rates following treatment with besifloxacin. RESULTS: Of 1041 subjects with culture-confirmed conjunctivitis, 17% had polybacterial and 83% had monobacterial conjunctivitis at baseline. In polybacterial compared to monobacterial infections, Haemophilus influenzae and Streptococcus pneumoniae were identified less frequently as the dominant infecting species (P = 0.042 and P<0.001, respectively), whereas Streptococcus mitis/S. mitis group was identified more frequently as dominant (P<0.001). Viral coinfection was also identified more frequently in polybacterial infections (P<0.001). Staphylococcus aureus was the most common coinfecting species in polybacterial infections and the second most common dominant species in such infections. With few exceptions, MICs for individual species were comparable regardless of infection type. Clinical microbial eradication rates with besifloxacin were high regardless of infection type (P≤0.016 vs vehicle at follow-up visits). CONCLUSIONS: TRIAL REGISTRATION: NCT000622908, NCT00347932, NCT00348348.
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Authors | Heleen H DeCory, Christine M Sanfilippo, Howard M Proskin, Joseph M Blondeau |
Journal | PloS one
(PLoS One)
Vol. 15
Issue 8
Pg. e0237603
( 2020)
ISSN: 1932-6203 [Electronic] United States |
PMID | 32841261
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Azepines
- Fluoroquinolones
- besifloxacin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(therapeutic use)
- Azepines
(therapeutic use)
- Bacteria
(classification, drug effects)
- Child
- Child, Preschool
- Conjunctivitis, Bacterial
(drug therapy, microbiology, pathology)
- Double-Blind Method
- Female
- Fluoroquinolones
(therapeutic use)
- Follow-Up Studies
- Humans
- Infant
- Infant, Newborn
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Prognosis
- Prospective Studies
- Young Adult
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