Vitamin C: A stem cell promoter in cancer metastasis and immunotherapy.

Abstract

Vitamin C is an electron donor and is involved in a variety of biochemical reactions in stem cell and cancer stem cell, as well as collagen synthesis and the regulation of hypoxia-inducible factor synthesis, which two affect extracellular matrix remodelling and hence cancer metastasis. Specific doses of vitamin C can stop cancer cell glycolysis and block nitroso synthesis, indicating the potential of vitamin C in cancer treatment. Recent studies preliminary revealed Vitamin C enhance the cancer's immune response to anti PD-L1 therapy through multiple indirect approaches. Herein we reviewed the recent function of vitamin C for further research in sequential aspects of cancer stem cell, extracellular matrix remodeling, cancer metastasis and cancer immunotherapy.

• Authors: Jingwen Fu, Zhaoyi Wu, Jianfeng Liu, Tianfu Wu
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 131 Pg. 110588 (Nov 2020) ISSN: 1950-6007 [Electronic] France
• PMID: 32836076 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Antioxidants
• B7-H1 Antigen
• CD274 protein, human
• Ascorbic Acid

Topics

• Animals
• Antioxidants (administration & dosage)
• Ascorbic Acid (administration & dosage)
• B7-H1 Antigen (antagonists & inhibitors, immunology)
• Extracellular Matrix (drug effects, immunology)
• Humans
• Immunotherapy (methods)
• Neoplasms (drug therapy, immunology)
• Neoplastic Stem Cells (drug effects, immunology)