Acquired platelet defect associated with gabapentin treatment: a case-report.

Abstract

Gabapentin, a structural analog of gamma-aminobutyric acid, is used to treat peripheral neuropathic pain. Here we report the first case of platelet function disorder associated with gabapentin treatment in a 44-year-old woman without a history of bleeding. She presented with mucocutaneous bleeding approximately 1 month after initiation of gabapentin and platelet function tests showed no aggregation to arachidonic acid and epinephrine, a defective response to ADP and a slightly decreased response to collagen. Gabapentin's imputability was supported by the fact that all platelet functions were normalized 6 days after drug discontinuation, with the simultaneous disappearance of bleedings.

• Authors: Tatiana Baglo, Claire Pouplard, Jean-Baptiste Valentin, Eve-Anne Guéry, Yves Gruel, Caroline Vayne
• Journal: Platelets (Platelets) Vol. 32 Issue 6 Pg. 846-849 (Aug 18 2021) ISSN: 1369-1635 [Electronic] England
• PMID: 32835556 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gabapentin

Topics

• Adult
• Blood Platelets (drug effects)
• Female
• Gabapentin (adverse effects, pharmacology)
• Hemorrhage (chemically induced)
• Humans
• Platelet Function Tests (methods)