Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation, and gut microbiome of high-fat diet-fed mice.

Abstract

Dietary fibers are essential components of a balanced diet and have beneficial effects on metabolic functions. To gain insight into their impact on host physiology and gut microbiota, we performed a direct comparison of two specific prebiotic fibers in mice. During an 8-wk follow up, mice fed a high-fat diet (HFD) were compared with mice on a normal diet (basal condition, controls) and to mice fed the HFD but treated with one of the following prebiotics: fructooligosaccharides (FOS) or soluble corn fiber (SCF). Both prebiotic fibers led to a similar reduction of body weight and fat mass, lower inflammation and improved metabolic parameters. However, these health benefits were the result of different actions of the fibers, as SCF impacted energy excretion, whereas FOS did not. Interestingly, both fibers had very distinct gut microbial signatures with different short-chain fatty acid profiles, indicating that they do not favor the growth of the same bacterial communities. Although the prebiotic potential of different fibers may seem physiologically equivalent, our data show that the underlying mechanisms of action are different, and this by targeting different gut microbes. Altogether, our data provide evidence that beneficial health effects of specific dietary fibers must be documented to be considered a prebiotic and that studies devoted to understanding how structures relate to specific microbiota modulation and metabolic effects are warranted.

• Authors: Matthias Van Hul, Kavita Karnik, Kirstie Canene-Adams, Mervyn De Souza, Pieter Van den Abbeele, Massimo Marzorati, Nathalie M Delzenne, Amandine Everard, Patrice D Cani
• Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab) Vol. 319 Issue 4 Pg. E779-E791 (10 01 2020) ISSN: 1522-1555 [Electronic] United States
• PMID: 32830554 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fiber
• Oligosaccharides
• fructooligosaccharide

Topics

• Animals
• Body Composition
• Body Weight
• Diet, High-Fat (adverse effects)
• Dietary Fiber (pharmacology)
• Energy Metabolism (drug effects)
• Gastrointestinal Microbiome (drug effects)
• Inflammation
• Insulin Resistance
• Male
• Metabolism (drug effects)
• Mice
• Mice, Inbred C57BL
• Oligosaccharides (pharmacology)
• Probiotics
• Zea mays