Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate-to-severe atopic dermatitis?

Abstract

The cutaneous microbiota responses to skin health as well as atopic dermatitis. To reveal the microbiota effect in atopic dermatitis children under therapy with topical corticosteroids and antibiotics. 59 atopic dermatitis patients were randomized to two treatment groups (by corticosteroids or combination therapy) in Beijing Children's Hospital. The lesion microbial samples were collected for 16S rDNA sequencing and bioinformatics analysis. After treatment, 57 patients recovered significantly. Though topical antibiotics application blocked the restoration of commensal Streptococcus, no remarkable differences of cutaneous microbiota were identified between the two groups along the treatment. In subject 1081, who received the combination therapy, the Streptococcus and Pseudomonas as well as Chryseobacterium increased dramatically. On the contrary, the Staphylococcus aureus decreased sharply in subject 1107 with topical corticosteroids treatment Our preliminary study suggested the necessity to consider cutaneous microbiota profile when prescribing antibiotics.

• Authors: Ying Liu, Qian Zhou, Wenkui Dai, Shan Wang, Yuan Liang, Yinhu Li, Chunping Shen, Dongfang Li, Yunzhu Li, Lei Jiao, Yawei Bian, Shuaicheng Li, Yi-Wei Tang, Lin Ma
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 33 Issue 6 Pg. e14215 (11 2020) ISSN: 1529-8019 [Electronic] United States
• PMID: 32827193 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Adrenal Cortex Hormones
• Anti-Bacterial Agents

Topics

• Administration, Topical
• Adrenal Cortex Hormones (adverse effects)
• Anti-Bacterial Agents (adverse effects)
• Child
• Dermatitis, Atopic (diagnosis, drug therapy)
• Humans
• Infant
• Prescriptions