Abstract | BACKGROUND: PATIENTS AND METHODS: A study of 59 acromegaly patients assessed thyroid nodules on ultrasound and fine-needle aspiration biopsy following the ATA 2015 criteria. We diagnosed 7 differentiated thyroid carcinomas. Resected thyroid carcinoma tissues were stained using an anti-AIP antibody. Analysis of germline and tumor-derived DNA for variants in the AIP and MEN1 genes were performed in the FIPA kindred. RESULTS: We describe one FIPA patient and 6 sporadic acromegaly cases with DTC. The FIPA family (AIP mutation negative) consisted of two sisters, one of whom had a DTC with intermediate risk and incomplete structural response to therapy. In our study, DTC in sporadic acromegaly had a low recurrence rate (6/6), and excellent response to therapy (6/6). Immunohistochemistry for AIP showed similar or increased staining intensity in DTC versus normal thyroid tissue. CONCLUSION: In our cohort of sporadic and familial forms of acromegaly with DTC, AIP did not appear to influence thyroid cancer progression.
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Authors | Amelia Rogozinski, Adrian F Daly, Adriana Reyes, Alejandra Furioso, Albert Beckers, Alicia Lowenstein |
Journal | Annales d'endocrinologie
(Ann Endocrinol (Paris))
Vol. 81
Issue 5
Pg. 482-486
(Oct 2020)
ISSN: 2213-3941 [Electronic] France |
PMID | 32822652
(Publication Type: Journal Article)
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Copyright | Copyright © 2020. Published by Elsevier Masson SAS. |
Topics |
- Acromegaly
(diagnostic imaging, epidemiology, etiology, pathology)
- Adenocarcinoma
(complications, diagnosis, epidemiology, pathology)
- Adenoma
(complications, diagnostic imaging, epidemiology, pathology)
- Adult
- Aged
- Argentina
(epidemiology)
- Biopsy, Fine-Needle
- Cohort Studies
- Comorbidity
- Disease Progression
- Female
- Germ-Line Mutation
- Growth Hormone-Secreting Pituitary Adenoma
(complications, diagnostic imaging, epidemiology, pathology)
- Humans
- Male
- Middle Aged
- Thyroid Neoplasms
(complications, diagnosis, epidemiology, pathology)
- Ultrasonography
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