Higher TIGIT+CD226- γδ T cells in Patients with Acute Myeloid Leukemia.

Abstract

The diverse structural and functional heterogeneity of γδ T cells is related to their distinct role in cancer immunity. The different phenotypes of γδ T cells in patients with acute myeloid leukemia (AML) is far from clear. In particular, the expression pattern of co-inhibitory and co-stimulatory receptors on γδ T cells remains unknown. In this study, we analyzed the distribution of γδ T cell subsets by expression of the immune checkpoint co-inhibitor TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain) and its competing co-stimulatory receptor CD226 in AML patients of different clinical statuses (including de novo AML, AML in non-remission (NR), and AML in complete remission (CR)). Our data demonstrated an imbalanced distribution of TIGIT and CD226 on γδ T cells with a decrease in CD226+ γδ T cells and an increase in TIGIT+ γδ T cells in de novo AML patients, while TIGIT-CD226+ γδ T cells were restored in AML patients who achieved CR after chemotherapy. Moreover, the patients who had higher TIGIT+CD226- γδ T cells showed lower overall survival rate for non-M3 AML, which may be considered a novel prognostic immune biomarker. In conclusion, our study reveals for the first time that imbalance in the TIGIT/CD226 axis might be related to different clinical outcomes for AML patients.Abbreviations: AML: acute myeloid leukemia; CR: complete remission; ICs: immune checkpoints; PD-1: programmed death-1; γδ T cells: gamma delta T cells; TCR: T cell receptor; MHC: major histocompatibility complex; TIGIT: T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain; NK: natural killer; PB: Peripheral blood; NR: non-remission; FAB: French-American-British; WHO: World Health Organization; HIs: healthy individuals; OS: overall survival.

• Authors: Zhenyi Jin, Tianbi Lan, Yun Zhao, Jinxia Du, Jie Chen, Jing Lai, Ling Xu, Shaohua Chen, Xueyun Zhong, Xiuli Wu, Yangqiu Li
• Journal: Immunological investigations (Immunol Invest) Vol. 51 Issue 1 Pg. 40-50 (Jan 2022) ISSN: 1532-4311 [Electronic] England
• PMID: 32819181 (Publication Type: Journal Article)

Chemical References

• Antigens, Differentiation, T-Lymphocyte
• Biomarkers
• Receptors, Immunologic
• TIGIT protein, human

Topics

• Antigens, Differentiation, T-Lymphocyte
• Biomarkers
• Humans
• Leukemia, Myeloid, Acute
• Receptors, Immunologic
• T-Lymphocyte Subsets