Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis.

Abstract

OBJECTIVE:

In recent years, a number of case-control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed.

METHODS:

Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case-control studies with 2890 cases and 3043 controls.

RESULTS:

This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population.

CONCLUSIONS:

Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

• Authors: Jie Liu, Chunrong Li, Xiaoyang Zhou, Jian Sun, Meng Zhu, Hongliang Zhang, Lei Cheng, Guobin Li, Tao He, Wenshuai Deng
• Journal: The Journal of international medical research (J Int Med Res) Vol. 48 Issue 8 Pg. 300060520947943 (Aug 2020) ISSN: 1473-2300 [Electronic] England
• PMID: 32814486 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• PARK7 protein, human
• Protein Deglycase DJ-1

Topics

• Asian People
• Case-Control Studies
• Genetic Predisposition to Disease
• Humans
• Odds Ratio
• Parkinson Disease (genetics)
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Protein Deglycase DJ-1