Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity.

Abstract

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

• Authors: Esmaeil Sheikh Ahmadi, Amir Tajbakhsh, Milad Iranshahy, Javad Asili, Nadine Kretschmer, Abolfazl Shakeri, Amirhossein Sahebkar
• Journal: Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 20 Issue 19 Pg. 2019-2035 ( 2020) ISSN: 1875-5607 [Electronic] Netherlands
• PMID: 32811411 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anti-Infective Agents
• Naphthoquinones
• lapachol

Topics

• Anti-Infective Agents (chemistry, isolation & purification, pharmacology)
• Apoptosis (drug effects)
• Drug Screening Assays, Antitumor
• Fungi (drug effects)
• Humans
• Naphthoquinones (chemistry, isolation & purification, pharmacology, therapeutic use)
• Neoplasms (drug therapy)
• Plants (chemistry, metabolism)
• Structure-Activity Relationship