Targeted NIRF/MR dual-mode imaging of breast cancer brain metastasis using BRBP1-functionalized ultra-small iron oxide nanoparticles.

Abstract

Tumor metastasis to brain is the main clinical manifestation of patients with advanced breast cancer, leading to poor survival prognosis. In order to detect the early incidence of brain metastasis, it is urgent to develop hypersensitive contrast agents for multimode imaging. In this study, PEG-phospholipids coated, a phage play derived peptide, BRBP1 peptide modified ultra-small iron oxide nanoparticles were prepared for targeted NIRF and MR imaging of breast cancer brain metastasis. The nanoparticles showed 10 nm core-shell, high relaxivity values and photon emission efficiency in vitro. The nanoparticles offered a T2 contrast imaging effect and near-infrared fluorescent signal enhancement. Compared with control peptide modified nanoparticles, the MR/NIRF imaging signal of BRBP1-modified nanoparticles in tumor tissue was significantly enhanced, which should be induced by the targeting ability of BRBP1 peptide. These results indicated that BRBP1-SPIO@mPEG (DiR) nanoparticles could be applied as an effective targeted delivery system for diagnosis of breast cancer brain metastasis.

• Authors: Jiawei Du, Ying Zhang, Zhangya Jin, Hao'an Wu, Jiehui Cang, Yuqing Shen, Fengqin Miao, Aifeng Zhang, Yu Zhang, Jianqiong Zhang, Gaojun Teng
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 116 Pg. 111188 (Nov 2020) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 32806329 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Contrast Media
• Magnetite Nanoparticles

Topics

• Brain Neoplasms (diagnostic imaging)
• Breast Neoplasms (diagnostic imaging)
• Cell Line, Tumor
• Contrast Media
• Humans
• Magnetic Iron Oxide Nanoparticles
• Magnetic Resonance Imaging
• Magnetite Nanoparticles
• Nanoparticles