Titanium coating with mussel inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against Staphylococcus aureus.
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| Abstract |
Implant-associated infections present severe and difficult-to-treat complications after surgery, related to implant biofilm colonization. Systemic administration of antibiotics cannot reach sufficient concentrations at the infected site and may be toxic. Here we describe how mussel-inspired dendritic material coated on a titanium surface can locally activate a prodrug of daptomycin (pro-dapto) to treat methicillin-resistant Staphylococcus aureus. The mechanism of the prodrug activation is based on bio-orthogonal click chemistry between a tetrazine (Tz) and trans-cyclooctene (TCO). The former is attached to the dendritic polymer, while the later converts daptomycin into a prodrug. Characterization of the material's properties revealed that it is hydrophobic, non-toxic, and stable for a prolonged period of time. We envision that the titanium coated dendritic material will be able to improve the treatment of implant-associated infections by concentrating systemically administered antibiotic prodrugs, thus converting them into active localized medicines.
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| Authors | Magdalena Czuban, Michaël W Kulka, Lei Wang, Anna Koliszak, Katharina Achazi, Christoph Schlaich, Ievgen S Donskyi, Mariagrazia Di Luca, Jose M Mejia Oneto, Maksim Royzen, Rainer Haag, Andrej Trampuz |
| Journal | Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 116 Pg. 111109 (Nov 2020) ISSN: 1873-0191 [Electronic] Netherlands |
| PMID | 32806230 (Publication Type: Journal Article) |
| Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
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